Formación
Postdoctoral studies - Research Fellow. National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), National Institutes of Health (NIH) 2002 – 2004
Ph.D. Biochemistry and Biophysics. Texas A&M University, College Station, TX
1997 – 2002
B.Sc. Microbiología. Universidad de Los Andes. Bogotá, Colombia 1988 – 1992
Área de trabajo
Interacciones celulares y moleculares que controlan la expresion de genes de organismos eucariotas.
Evolución de los elementos de regulacion genetica en eucariotas.
Diseño e implementacion de bases de datos biológicos con aplicaciones en genomica y metagenómica.
Asociacion genomica para mejoramiento vegetal y animal.
El establecimiento de programas en Biología computacional y Bioinformática es fundamental para el entendimiento de la avalancha de datos genómicos presentes en las bases de datos públicas. Esta afirmacion es válida para cualquier sistema biológico incluyendo plantas, animales o microorganismos. Yo le brindo a la corporación 16 años de experiencia en investigación con un portafolio que incluye microbiología, bioquímica, genética y bioinformática construido en una variedad de centros de investigacion de alto prestigio nacional e internacional.
Publicaciones
Expression patterns of protein kinases correlate with gene architecture and evolutionary rates.
PLoS ONE. 2008;3(10):e3599. Epub 2008 Oct 31.
PMID: 18974838 [PubMed - in process]
Finding sequence motifs with Bayesian models incorporating positional information: an application to transcription factor binding sites.
BMC Bioinformatics. 2008 Jun 4;9:262.
PMID: 18533028 [PubMed - indexed for MEDLINE]
Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA.
BMC Genomics. 2008 May 17;9:226.
PMID: 18485226 [PubMed - indexed for MEDLINE]
The biological function of some human transcription factor binding motifs varies with position relative to the transcription start site.
Nucleic Acids Res. 2008 May;36(8):2777-86. Epub 2008 Mar 26.
PMID: 18367472 [PubMed - indexed for MEDLINE]
Co-evolutionary Rates of Functionally Related Yeast Genes.
Evol Bioinform Online. 2006;2:295-300.
PMID: 18345352 [PubMed]
Widespread positive selection in synonymous sites of mammalian genes.
Mol Biol Evol. 2007 Aug;24(8):1821-31. Epub 2007 May 23.
PMID: 17522087 [PubMed - indexed for MEDLINE]
Origin and evolution of human microRNAs from transposable elements.
Genetics. 2007 Jun;176(2):1323-37. Epub 2007 Apr 15.
PMID: 17435244 [PubMed - indexed for MEDLINE]
TLX1/HOX11-induced hematopoietic differentiation blockade.
Oncogene. 2007 Jun 14;26(28):4115-23. Epub 2007 Jan 8.
PMID: 17213805 [PubMed - indexed for MEDLINE]
Multiple independent evolutionary solutions to core histone gene regulation.
Genome Biol. 2006;7(12):R122.
PMID: 17184543 [PubMed - indexed for MEDLINE]
Global similarity and local divergence in human and mouse gene co-expression networks.
BMC Evol Biol. 2006 Sep 12;6:70.
PMID: 16968540 [PubMed - indexed for MEDLINE]
Scanning sequences after Gibbs sampling to find multiple occurrences of functional elements.
BMC Bioinformatics. 2006 Sep 8;7:408.
PMID: 16961919 [PubMed - indexed for MEDLINE]
Transposable element derived DNaseI-hypersensitive sites in the human genome.
Biol Direct. 2006 Jul 20;1:20.
PMID: 16857058 [PubMed]
The Histone Database: a comprehensive resource for histones and histone fold-containing proteins.
Proteins. 2006 Mar 1;62(4):838-42.
PMID: 16345076 [PubMed - indexed for MEDLINE]
Histone structure and nucleosome stability.
Expert Rev Proteomics. 2005 Oct;2(5):719-29. Review.
PMID: 16209651 [PubMed - indexed for MEDLINE]
Global regulation by the yeast Spt10 protein is mediated through chromatin structure and the histone upstream activating sequence elements.
Mol Cell Biol. 2005 Oct;25(20):9127-37.
PMID: 16199888 [PubMed - indexed for MEDLINE]
Transposable elements donate lineage-specific regulatory sequences to host genomes.
Cytogenet Genome Res. 2005;110(1-4):333-41. Review.
PMID: 16093685 [PubMed - indexed for MEDLINE]
Alignments anchored on genomic landmarks can aid in the identification of regulatory elements.
Bioinformatics. 2005 Jun;21 Suppl 1:i440-8.
PMID: 15961489 [PubMed - indexed for MEDLINE]
Evolutionary significance of gene expression divergence.
Gene. 2005 Jan 17;345(1):119-26. Epub 2004 Dec 29.
PMID: 15716085 [PubMed - indexed for MEDLINE]
Conservation and coevolution in the scale-free human gene coexpression network.
Mol Biol Evol. 2004 Nov;21(11):2058-70. Epub 2004 Jul 28.
PMID: 15282333 [PubMed - indexed for MEDLINE]
Identification and mapping of self-assembling protein domains encoded by the Escherichia coli K-12 genome by use of lambda repressor fusions.
Statistical analysis of over-represented words in human promoter sequences.
Nucleic Acids Res. 2004 Feb 12;32(3):949-58. Print 2004. Erratum in: Nucleic Acids Res. 2004 Dec;32(22):6718. Nucleic Acids Res. 2004 Nov 8;32(19):5972.
PMID: 14963262 [PubMed - indexed for MEDLINE]
Screening peptide/protein libraries fused to the lambda repressor DNA-binding domain in E. coli cells.
Methods Mol Biol. 2003;205:235-50. No abstract available.
PMID: 12491891 [PubMed - indexed for MEDLINE]
Isolation and mapping of self-assembling protein domains encoded by the Saccharomyces cerevisiae genome using lambda repressor fusions.
Yeast. 2002 May;19(7):641-50.
PMID: 11967834 [PubMed - indexed for MEDLINE] |
